Pesquisa | BVS Integralidade em Saúde

1.

Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis.

Kwok, Andrew J; Allcock, Alice; Ferreira, Ricardo C; Cano-Gamez, Eddie; Smee, Madeleine; Burnham, Katie L; Zurke, Yasemin-Xiomara; McKechnie, Stuart; Mentzer, Alexander J; Monaco, Claudia; Udalova, Irina A; Hinds, Charles J; Todd, John A; Davenport, Emma E; Knight, Julian C.

Nat Immunol ; 24(5): 767-779, 2023 05.

Artigo em Inglês | MEDLINE | ID: mdl-37095375

2.

Author Correction: Approaches and advances in the genetic causes of autoimmune disease and their implications.

Inshaw, Jamie R J; Cutler, Antony J; Burren, Oliver S; Stefana, M Irina; Todd, John A.

Nat Immunol ; 21(6): 695, 2020 06.

Artigo em Inglês | MEDLINE | ID: mdl-32296167

3.

Publisher Correction: Approaches and advances in the genetic causes of autoimmune disease and their implications.

Inshaw, Jamie R J; Cutler, Antony J; Burren, Oliver S; Stefana, M Irina; Todd, John A.

Nat Immunol ; 20(3): 375, 2019 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-30728494

4.

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters.

Javierre, Biola M; Burren, Oliver S; Wilder, Steven P; Kreuzhuber, Roman; Hill, Steven M; Sewitz, Sven; Cairns, Jonathan; Wingett, Steven W; Várnai, Csilla; Thiecke, Michiel J; Burden, Frances; Farrow, Samantha; Cutler, Antony J; Rehnström, Karola; Downes, Kate; Grassi, Luigi; Kostadima, Myrto; Freire-Pritchett, Paula; Wang, Fan; Stunnenberg, Hendrik G; Todd, John A; Zerbino, Daniel R; Stegle, Oliver; Ouwehand, Willem H; Frontini, Mattia; Wallace, Chris; Spivakov, Mikhail; Fraser, Peter.

Cell ; 167(5): 1369-1384.e19, 2016 11 17.

Artigo em Inglês | MEDLINE | ID: mdl-27863249

5.

Approaches and advances in the genetic causes of autoimmune disease and their implications.

Inshaw, Jamie R J; Cutler, Antony J; Burren, Oliver S; Stefana, M Irina; Todd, John A.

Nat Immunol ; 19(7): 674-684, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29925982

6.

Metagenomics and personalized medicine.

Virgin, Herbert W; Todd, John A.

Cell ; 147(1): 44-56, 2011 Sep 30.

Artigo em Inglês | MEDLINE | ID: mdl-21962506

7.

Tau depletion in human neurons mitigates Aß-driven toxicity.

Ng, Bryan; Vowles, Jane; Bertherat, Féodora; Abey, Ajantha; Kilfeather, Peter; Beccano-Kelly, Dayne; Stefana, M Irina; O'Brien, Darragh P; Bengoa-Vergniory, Nora; Carling, Phillippa J; Todd, John A; Caffrey, Tara M; Connor-Robson, Natalie; Cowley, Sally A; Wade-Martins, Richard.

Mol Psychiatry ; 2024 Feb 15.

Artigo em Inglês | MEDLINE | ID: mdl-38361127

8.

D'oh! genes and environment cause Crohn's disease.

Todd, John A.

Cell ; 141(7): 1114-6, 2010 Jun 25.

Artigo em Inglês | MEDLINE | ID: mdl-20602995

9.

The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults.

Marcovecchio, M Loredana; Hendriks, A Emile J; Delfin, Carl; Battelino, Tadej; Danne, Thomas; Evans, Mark L; Johannesen, Jesper; Kaur, Simranjeet; Knip, Mikael; Overbergh, Lut; Pociot, Flemming; Todd, John A; Van der Schueren, Bart; Wicker, Linda S; Peakman, Mark; Mathieu, Chantal.

Diabetologia ; 67(6): 995-1008, 2024 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-38517484

10.

Early-childhood body mass index and its association with the COVID-19 pandemic, containment measures and islet autoimmunity in children with increased risk for type 1 diabetes.

Hummel, Sandra; Rosenberger, Sarah; von dem Berge, Thekla; Besser, Rachel E J; Casteels, Kristina; Hommel, Angela; Kordonouri, Olga; Elding Larsson, Helena; Lundgren, Markus; Marcus, Benjamin A; Oltarzewski, Mariusz; Rochtus, Anne; Szypowska, Agnieszka; Todd, John A; Weiss, Andreas; Winkler, Christiane; Bonifacio, Ezio; Ziegler, Anette-G.

Diabetologia ; 67(4): 670-678, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38214711

11.

Genomic atlas of the human plasma proteome.

Sun, Benjamin B; Maranville, Joseph C; Peters, James E; Stacey, David; Staley, James R; Blackshaw, James; Burgess, Stephen; Jiang, Tao; Paige, Ellie; Surendran, Praveen; Oliver-Williams, Clare; Kamat, Mihir A; Prins, Bram P; Wilcox, Sheri K; Zimmerman, Erik S; Chi, An; Bansal, Narinder; Spain, Sarah L; Wood, Angela M; Morrell, Nicholas W; Bradley, John R; Janjic, Nebojsa; Roberts, David J; Ouwehand, Willem H; Todd, John A; Soranzo, Nicole; Suhre, Karsten; Paul, Dirk S; Fox, Caroline S; Plenge, Robert M; Danesh, John; Runz, Heiko; Butterworth, Adam S.

Nature ; 558(7708): 73-79, 2018 06.

Artigo em Inglês | MEDLINE | ID: mdl-29875488

12.

Constitutive antiviral immunity at the expense of autoimmunity.

Todd, John A.

Immunity ; 40(2): 167-9, 2014 Feb 20.

Artigo em Inglês | MEDLINE | ID: mdl-24560191

13.

Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics.

Ghoussaini, Maya; Mountjoy, Edward; Carmona, Miguel; Peat, Gareth; Schmidt, Ellen M; Hercules, Andrew; Fumis, Luca; Miranda, Alfredo; Carvalho-Silva, Denise; Buniello, Annalisa; Burdett, Tony; Hayhurst, James; Baker, Jarrod; Ferrer, Javier; Gonzalez-Uriarte, Asier; Jupp, Simon; Karim, Mohd Anisul; Koscielny, Gautier; Machlitt-Northen, Sandra; Malangone, Cinzia; Pendlington, Zoe May; Roncaglia, Paola; Suveges, Daniel; Wright, Daniel; Vrousgou, Olga; Papa, Eliseo; Parkinson, Helen; MacArthur, Jacqueline A L; Todd, John A; Barrett, Jeffrey C; Schwartzentruber, Jeremy; Hulcoop, David G; Ochoa, David; McDonagh, Ellen M; Dunham, Ian.

Nucleic Acids Res ; 49(D1): D1311-D1320, 2021 01 08.

Artigo em Inglês | MEDLINE | ID: mdl-33045747

14.

SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood.

Lugar, Marija; Eugster, Anne; Achenbach, Peter; von dem Berge, Thekla; Berner, Reinhard; Besser, Rachel E J; Casteels, Kristina; Elding Larsson, Helena; Gemulla, Gita; Kordonouri, Olga; Lindner, Annett; Lundgren, Markus; Müller, Denise; Oltarzewski, Mariusz; Rochtus, Anne; Scholz, Marlon; Szypowska, Agnieszka; Todd, John A; Ziegler, Anette-Gabriele; Bonifacio, Ezio.

JAMA ; 330(12): 1151-1160, 2023 09 26.

Artigo em Inglês | MEDLINE | ID: mdl-37682551

15.

Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage.

Sioofy-Khojine, Amir-Babak; Richardson, Sarah J; Locke, Jonathan M; Oikarinen, Sami; Nurminen, Noora; Laine, Antti-Pekka; Downes, Kate; Lempainen, Johanna; Todd, John A; Veijola, Riitta; Ilonen, Jorma; Knip, Mikael; Morgan, Noel G; Hyöty, Heikki; Peakman, Mark; Eichmann, Martin.

Diabetologia ; 65(10): 1701-1709, 2022 10.

Artigo em Inglês | MEDLINE | ID: mdl-35867130

16.

Using de novo assembly to identify structural variation of eight complex immune system gene regions.

Zhang, Jia-Yuan; Roberts, Hannah; Flores, David S C; Cutler, Antony J; Brown, Andrew C; Whalley, Justin P; Mielczarek, Olga; Buck, David; Lockstone, Helen; Xella, Barbara; Oliver, Karen; Corton, Craig; Betteridge, Emma; Bashford-Rogers, Rachael; Knight, Julian C; Todd, John A; Band, Gavin.

PLoS Comput Biol ; 17(8): e1009254, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-34343164

17.

Analysis of overlapping genetic association in type 1 and type 2 diabetes.

Inshaw, Jamie R J; Sidore, Carlo; Cucca, Francesco; Stefana, M Irina; Crouch, Daniel J M; McCarthy, Mark I; Mahajan, Anubha; Todd, John A.

Diabetologia ; 64(6): 1342-1347, 2021 06.

Artigo em Inglês | MEDLINE | ID: mdl-33830302

18.

PRF1 mutation alters immune system activation, inflammation, and risk of autoimmunity.

Sidore, Carlo; Orrù, Valeria; Cocco, Eleonora; Steri, Maristella; Inshaw, Jamie Rj; Pitzalis, Maristella; Mulas, Antonella; McGurnaghan, Stuart; Frau, Jessica; Porcu, Eleonora; Busonero, Fabio; Dei, Mariano; Lai, Sandra; Sole, Gabriella; Virdis, Francesca; Serra, Valentina; Poddie, Fausto; Delitala, Alessandro; Marongiu, Michele; Deidda, Francesca; Pala, Mauro; Floris, Matteo; Masala, Marco; Onengut-Gumuscu, Suna; Robertson, Catherine C; Leoni, Lidia; Frongia, Annapaola; Ricciardi, Maria Rossella; Chessa, Margherita; Olla, Nazario; Lovicu, Mario; Loizedda, Annalisa; Maschio, Andrea; Mereu, Luisa; Ferrigno, Paola; Curreli, Nicolo; Balaci, Lenuta; Loi, Francesco; Ferreli, Liana Ap; Pilia, Maria Grazia; Pani, Antonello; Marrosu, Maria Giovanna; Abecasis, Goncalo R; Rich, Stephen S; Colhoun, Helen; Todd, John A; Schlessinger, David; Fiorillo, Edoardo; Cucca, Francesco; Zoledziewska, Magdalena.

Mult Scler ; 27(9): 1332-1340, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-33566725

19.

Etiology of type 1 diabetes.

Todd, John A.

Immunity ; 32(4): 457-67, 2010 Apr 23.

Artigo em Inglês | MEDLINE | ID: mdl-20412756

20.

Identification of infants with increased type 1 diabetes genetic risk for enrollment into Primary Prevention Trials-GPPAD-02 study design and first results.

Winkler, Christiane; Haupt, Florian; Heigermoser, Martin; Zapardiel-Gonzalo, Jose; Ohli, Jasmin; Faure, Theresa; Kalideri, Evdokia; Hommel, Angela; Delivani, Petrina; Berner, Reinhard; Kordonouri, Olga; Roloff, Frank; von dem Berge, Thekla; Lange, Karin; Oltarzewski, Mariusz; Glab, Ryszard; Szypowska, Agnieszka; Snape, Matthew D; Vatish, Manu; Todd, John A; Larsson, Helena E; Ramelius, Anita; Kördel, Jeanette Å; Casteels, Kristina; Paulus, Jasmin; Ziegler, Anette G; Bonifacio, Ezio.

Pediatr Diabetes ; 20(6): 720-727, 2019 09.

Artigo em Inglês | MEDLINE | ID: mdl-31192505

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Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis.

Author Correction: Approaches and advances in the genetic causes of autoimmune disease and their implications.

Publisher Correction: Approaches and advances in the genetic causes of autoimmune disease and their implications.

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters.

Approaches and advances in the genetic causes of autoimmune disease and their implications.

Metagenomics and personalized medicine.

Tau depletion in human neurons mitigates Aß-driven toxicity.

D'oh! genes and environment cause Crohn's disease.

The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults.

Early-childhood body mass index and its association with the COVID-19 pandemic, containment measures and islet autoimmunity in children with increased risk for type 1 diabetes.

Genomic atlas of the human plasma proteome.

Constitutive antiviral immunity at the expense of autoimmunity.

Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics.

SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood.

Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage.

Using de novo assembly to identify structural variation of eight complex immune system gene regions.

Analysis of overlapping genetic association in type 1 and type 2 diabetes.

PRF1 mutation alters immune system activation, inflammation, and risk of autoimmunity.

Etiology of type 1 diabetes.

Identification of infants with increased type 1 diabetes genetic risk for enrollment into Primary Prevention Trials-GPPAD-02 study design and first results.